TurboCRAZED BOLD imaging detects specific activation in the rat brain after somatosensory stimulation at 16.4 Tesla
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چکیده
Introduction Studies on humans at clinical field strengths have shown that the blood oxygen level dependent (BOLD) effect is increased in images acquired with pulse sequences detecting intermolecular multiple-quantum coherences (iMQC). Recently, hyperoxia-induced global BOLD contrast was observed in anesthetized mice [1] and rats [2] with the novel iMQC-imaging sequence TurboCRAZED. The aim of this study was to adapt TurboCRAZED for longitudinal fMRI with somatosensory stimulation on rats under extensive physiological monitoring at 16.4 T, and to detect specific activation with iMQC-imaging in animals.
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تاریخ انتشار 2008